Canadian researchers will study whether the plasma of recovered patients can be used to treat COVID-19, in an April 9, 2020 story. (Photo by THE CANADIAN PRESS)

Canadian researchers will study whether the plasma of recovered patients can be used to treat COVID-19, in an April 9, 2020 story. (Photo by THE CANADIAN PRESS)

Researchers to study whether plasma of recovered patients can treat COVID-19

Plasma is the liquid portion of the blood that contains the antibodies that protect against illness

Researchers from across Canada will collaborate on a vast clinical trial to study whether the plasma of recovered patients can be used to treat COVID-19.

The study, the largest to date ever done on the subject, will include about 50 Canadian institutions, including 15 in Quebec.

“It’s a therapy to treat the illness,” said one of the lead researchers, Dr. Philippe Begin of Montreal’s CHU Ste-Justine hospital.

“We’re talking about passive immunizations, while with a vaccine we’re talking about active immunization.”

Passive immunization consists of transfusing plasma from patients who have recovered from COVID-19 — called convalescent plasma — to patients in the early stages of the illness in order to provide protective antibodies and hopefully limit the severity of symptoms.

Plasma is the liquid portion of the blood that contains the antibodies that protect against illness.

Begin cited the proverb, “Give a man a fish and feed him for a day; teach a man to fish and feed him for a lifetime.” Teaching someone to fish, he said, would be the equivalent of a vaccine that prompts the body to make its own antibodies.

But with no vaccine available, convalescent plasma is the best alternative.

ALSO READ: ‘Tremendous’ response from blood donors has supply keeping pace with demand

“But now we don’t have time, because we don’t yet know how to fish, so we can’t really teach it,” he said. “So the idea is that we just give the antibodies created by someone else.”

The approach was used before the development of vaccines to combat epidemics, and it’s not the first time the idea of using convalescent plasma has been raised in the fight against COVID-19. But thus far, the evidence in favour remains largely anecdotal and of poor scientific quality.

The study will include researchers from the Universite de Montreal, the Jewish General Hospital in Montreal, Hema-Quebec, McMaster University, and Sunnybrook and SickKids hospitals in Toronto, among others.

Begin admitted researchers are running “a little blind” when it comes to the use of plasma.

“We don’t have a ton of studies that tell us, it takes this kind of antibody, or this amount of plasma,” he said.

The best way to get answers is to assemble as much data as possible, as quickly as possible, he said.

“We want to go fast, and the best way to go fast is have several of us following the same protocol to put all the data together,” he said.

“We have colleagues in other countries who are interested and with whom we share our protocols.”

Plasma will be collected about a month after a patient recovers, when antibody levels are at their highest. COVID-19 was first reported in Quebec in late February, and the number of potential donors in the province remains low, although it’s growing.

Therefore, the researchers have decided the convalescent plasma will be reserved for those who are suffering from the illness, although it’s not out of the question that it could be offered later to at-risk groups, such as health-care workers, as a preventive measure.

The study is expected to last about three months and involve more than 1,000 patients.

Jean-Benoit Legault, The Canadian Press

Like us on Facebook and follow us on Twitter.

Coronavirus

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

(file)
Two ejected from single vehicle crash in Seabird Island

Landing zone for medevac has been requested

(File photo)
Semi truck and car collide on Highway 1 near Popkum

Slow lane eastbound is now closed as crews wait for tow trucks

Treeplanters from Shakti Reforestation are adding to the forests of Mount Thom Park. (City of Chilliwack)
Treeplanting project in Mount Thom Park will keep Chilliwack forest resilient

So far they’ve planted 2,000 of 80,000 trees planned for popular park on Promontory

Fire damage is seen in the windows of an apartment on Yale Road on April 21, 2021 following a fire there the night before. (Jenna Hauck/ Chilliwack Progress)
Chilliwack Fire Dept. reminds people again to have working smoke alarms following 2nd blaze in 2 days

All six halls responded to bedroom fire in apartment on Yale Road above restaurant in Chilliwack

Bert Brink Wildlife Management Area was the site of illegally dumped drywall reported on April 19, 2021. (Michael Hill photo)
Another cache of dumped drywall in Chilliwack prompts suggestion to block access

Pile of drywall likely asbestos containing discarded in wildlife management area

A large crowd protested against COVID-19 measures at Sunset Beach in Vancouver on Tuesday, April 20, 2021. (Snapchat)
VIDEO: Large, police-patrolled crowds gather at Vancouver beach for COVID protests

Vancouver police said they patrolled the area and monitored all gatherings

Thousands have converged in Whonnock Lake Park to enjoy the nice weather. (Roxanne Hooper/The News)
Thousands enjoy B.C. park with warnings about social distancing

Portable toilets installed in anticipation of nice weather

FILE – The Instagram app is shown on an iPhone in Toronto on Monday, March 19, 2018. THE CANADIAN PRESS/Graeme Roy
Judge acquits B.C. teen boy ‘set up’ on sex assault charge based on Instagram messages

The girl and her friends did not have ‘good intentions’ towards the accused, judge says

Kai Palkeinen recently helped a car stuck on the riverbed near the Big Eddy Bridge. While the car could not be saved, some of the driver’s belongings were. It’s common for vehicles to get stuck in the area due to significantly changing river levels from Revelstoke Dam. (Photo by Kai Palkeinen)
“I just sank a car’: Revelstoke resident tries to save vehicle from the Columbia River

Although it’s not permitted, the riverbed near the city is popular for off roading

Cannabis bought in British Columbia (Ashley Wadhwani/Black Press Media)
Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

Playland at the PNE is set to reopen this May, with COVID-19 health and safety measures approved by the province. (Website/Playland)
VIDEO: Playland at PNE scheduled to reopen this May to masked customers

British Columbians are discouraged from travelling outside of their local health authority to visit the theme park

Meng Wanzhou, chief financial officer of Huawei, walks down the street with an acquaintance after leaving B.C. Supreme Court during a lunch break at her extradition hearing, in Vancouver, B.C., Thursday, April 1, 2021. A judge is scheduled to release her decision today on a request to delay the final leg of hearings in Meng Wanzhou’s extradition case. THE CANADIAN PRESS/Rich Lam
B.C. judge grants Meng Wanzhou’s request to delay extradition hearings

Lawyers for Canada’s attorney general had argued there is no justification to delay proceedings in the case

B.C. Premier John Horgan announces travel restrictions between the province’s regional health authorities at the legislature, April 19, 2021. (B.C. government photo)
B.C. sees 862 more COVID-19 cases Wednesday, seven deaths

Recreational travel restrictions set to begin Friday

B.C. Finance Minister Selina Robinson is photographed following her budget speech in the legislative assembly at the provincial legislature in Victoria, Tuesday, April 20, 2021. THE CANADIAN PRESS/Chad Hipolito
B.C. budget lacks innovative drive, vision during uncertain times, say experts

Finance Minister Selina Robinson’s budget sets out to spend $8.7 billion over three years on infrastructure

Most Read